Defects in articular cartilage can induce osteoarthritis by causing molecular changes in the synovial fluid. Research in molecular biology discovered the major inducer of osteoarthritis was the general inflammatory cytokine interleukin- 1 (IL-1) which plays a key role in accelerating tissue destruction and the repair mechanisms.
In a healthy joint, IL-1 and interleukin-1 receptor antagonist (IL-1Ra) are in balanced concentrations. In cases of osteoarthritis, there is not sufficient IL-1Ra produced to block the destructive effects of the increased IL-1. The result is inflammation, joint pain, and eventually cartilage destruction. In the Arthrex ABPS, monocytes (a type of white blood cell) bind to the glass beads. The cells are then stimulated to produce regenerative and anti-inflammatory proteins without the addition of drugs. This process takes place over an incubation period of 16-22 hours.
|Product description||Item number|
|Arthrex ABPS (a) Kit contains one Arthrex ABPS device
with dual ports, one 60 ml syringe and one butterfly cannula
|Labnet Mini Incubator, compact general purposes 230V||VAR-1040|
|Centrifuge Hettich Rotofix 32A, 220 V (b)||VABS-10019|
|Hettich Fixed Angle Rotor 1620A for Centrifuge Rotofix 32A||VAR-1021|
|ABPS Counterweight for Centrifugation (c)||VAR-1012-1|
|Adaptor for bucket 38/80, qty. 2||VABS-10030|
In osteoarthritis, IL-1 is produced in large amounts and binds to receptor sites on the cartilage signaling cell destruction.
Introduction of Arthrex ABPS serum into the joint.
In the Arthrex ABPS System, monocytes bind to the beads stimulating the regenerative and anti-inflammatory proteins during incubation.
The Arthrex ABPS serum has high concentrations of regenerative and inhibitory proteins that block the effects of destructive proteins like IL-1, by filling the receptors on the cartilage with IL-1Ra.
Incubation-Rack for Arthrex ABPS – available upon request.
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